The paper analyzes current situation of the non-medical majors and literature information retrieval course in Traditional Chinese Medicine(TCM) colleges and universities, points out the course reform objectives and key points. By taking Liaoning University of Traditional Chinese Medicine as an example, it discusses the characteristics of non-medical majors and needs for the literature information retrieval course, and proposes the teaching approach of literature information retrieval course for non-medical majors in TCM colleges and universities.