Purpose/Significance To achieve cross-province interoperability of electronic vaccination certificates，so as to enhance the continuity and management efficiency of public health services. Method/Process By analyzing cross-province interoperability busi. ness scenarios and data consistency requirements，an integrated technical solution is proposed，featuring the national platform as the co. ordination hub，event-driven as the core，three-tier hierarchical logical architecture as the support，and multi-level caching and con. flict resolution as the guarantee. Result/Conclusion The solution achieves business closed-loop management based on the“one person， one file，one certificate”rule，ensuring business continuity and data consistency. It not only lays a solid technical foundation for the con.struction of electronic vaccination certificate systems across the country but also offers a reference solution for cross-regional collabora.tion in other government services.