In order to know influenza epidemic situation such as morbidity and mortality as well as preventive measures in China when Spanish influenza happened in 1918, the paper carries out comprehensive analysis based on full-scale literatures review. It points out that influenza did happen in China when Spanish influenza brought vital prevalence over the world and the youth were the susceptible population, the mortality of young adults is higher during this disaster, however, comparing to foreign countries mortality in China was lower. Traditional Chinese medicine was the main methods and means for preventing and curing the disease.