The paper introduces the building of monitoring system of Acute Febrile Illness(AFI) on the basis of the Epidemiological Dynamic Data Collection (EDDC) platform, elaborates the design and implementation of the system from the aspects of business process, functional module and so on, and analyzes in detail its data collection, logical checking, data management, user management, data visualization, system management and other functions, pointing out that the system can simplify work flow and improve monitoring efficiency and quality.