The paper analyzes the status quo of data quality management of the hospital's medical record homepages and effect of relevant knowledge base, takes Puning People's Hospital as an example to elaborate building procedures and content of data quality control knowledge base of medical record homepages, compares and analyzes data filling-in quality of medical record homepages before and after the knowledge base building, and the result shows that application of the knowledge base can lower filling-in defect rate and help improve data quality of medical record homepages.