The paper introduces the establishment and theoretical basis of Traditional Chinese Medicine (TCM) informatics, elaborates the research progress in the field of TCM information engineering technology from the aspects of TCM ancient books digitization project, TCM scientific data joint construction and sharing project, TCM information standardization project and TCM knowledge engineering, discusses the research progress of TCM information application science by reviewing the research of TCM clinical informatics, Chinese medicine informatics, computational acupuncture and TCM information science, illustrates the development and discipline status of TCM informatics education, as well as its discipline classification, and provides useful references for the research of TCM informatics.