Purpose/Significance Based on the real data of the pediatric prescription circulation platform, a comparative study on user characteristics is carried out in order to improve the pediatric prescription circulation service and related platform construction in China, and to provide references for improving the service capability of the prescription circulation platform. Method/Process Information of children who purchase drugs through the prescription circulation platform of Beijing Children’s Hospital from September 10,2019 to July 31,2023 is collected and divided into online drug purchasing group and offline drug purchasing group according to drug access. JMP 17.0 (SAS) statistical analysis is used, and Pearson χ² test is used for comparison between groups. Result/Conclusion There are statistically significant differences in social demographic characteristics, medical behavior characteristics and single prescription characteristics between the two groups. The pediatric prescription circulation platform has great potential in medical alliance, and online mode is a good application scenario to realize cross-hospital drug circulation. Measures such as building multi-center online drug logistics centers and offline pharmacies according to different user groups can effectively improve the service capability of the platform.