Purpose/Significance To probe into the role and the realization path of hospital library in proof-of-concept, and to provide references for proof-of-concept service of library and improving the effectiveness of proof-of-concept.Method/Process Through literature research, the influencing factors, process steps, potential problems and impact of proof-of-concept on the transformation of results are expounded. The proof-of-concept model is constructed according to the logic of “cause and effect”, the main role and derivative role of library are discussed in combination with resource and service elements, and the corresponding library functions in the derivative role are explored and the realization path of library in the proof-of-concept is expounded.Result/Conclusion Proof-of-concept is an important means to accelerate the transformation of scientific and technological achievements. Hospital library mainly plays four roles in proof-of-concept, such as activation of driving factors, and can promote the implementation of proof-of-concept around six functions, such as collection construction, cultural construction, collaborative management, etc.