Purpose/Significance By summarizing the construction experience of the immunology database and analysis portal(ImmPort), the study aims to provide insights and references for the development of a large-scale immunology database in China. Method/Process It comprehensively analyzes the architecture of ImmPort and the functionalities of its various modules, and delineates the data flow for data collection, organization, sharing, and analysis within the database. Finally, it summarizes the practical achievements of the ImmPort platform. Result/Conclusion In the process of constructing the immunology database, our country should prioritize the standardization of data organization and modeling. Standardized terminology should be actively adopted to provide semantic support, and data sharing should be carried out in the management of classification and grading, while developing a supporting tool system to ensure the safe and effective sharing and utilization of immunology data.