Purpose/Significance To construct a specialized disease database based on structured electronic medical records (EMR), and to improve the standardization and usability of the specialized disease database and improve the efficiency of clinical scientific research. Method/Process By using templated input, natural language processing (NLP) and other technologies, unstructured EMR are converted into structured EMR, and a specialized disease database is constructed based on structured EMR. Result/Conclusion The psoriasis specialized disease database sub center built by Longhua Hospital based on structured EMR provides clinical researchers with a structured scientific research data source, assists researchers in improving analysis efficiency, and effectively supports the construction of Shanghai Shenkang’s “multi center psoriasis specialized disease big data clinical research follow-up integrated platform”, which is conducive to the high-quality and large-scale development of specialized disease databases.