Purpose/Significance To explore the influencing factors and interaction mechanism of health anxiety and health information seeking behavior. Method/Process Cross-sectional studies on the relationship between health anxiety and health information seeking behavior in recent years are searched from PubMed, WoS and CNKI, and literature analysis is conducted. Result/Conclusion Health information seeking behavior, perception, intolerable uncertainty and information characteristics have important effects on health anxiety. Health anxiety, health information literacy, self-efficacy and behavioral intention have important effects on health information seeking behavior, health anxiety and health information seeking behavior interact through mediating factors.