Purpose/Significance To evaluate the quality of disease-related health information in mobile social media, and to provide a basis for the management of such information. Method/Process The evaluation index system of disease-related health information in mobile social media is established by using Delphi method, and the weight of the index is determined with analytic hierarchy process (AHP), and an empirical study is conducted on disease-related health information in WeChat official account. Result/Conclusion It is necessary to establish an evaluation index system of disease-related health information in mobile social media. The evaluation index system established in this study is scientific and can be used for evaluating text and short video related information.