Purpose/Significance Using information technology to achieve cross-provincial sharing of vaccination records, and to further improve the information service capabilities of immunization program. Method/Process Based on the status of immunization program information systems in China, the business process for cross-provincial sharing of vaccination records is designed, the vaccination information is queried and transmitted by means of interface, and data verification and security control methods are used to ensure the accuracy and reliability of the data. Result/Conclusion Through the joint debugging test between the national and pilot provincial platforms, it has been verified that the business processes are feasible and the system functions are usable. The process of cross-provincial sharing of vaccination records involves much tache and requires strong collaboration among provinces, so it is necessary to continuously strengthen the management of data standardization and normalization, to improve the consistency and timeliness of data flow, and to realize the goal of real-time cooperating work in various provinces and closed-loop management with “one vaccination record per person”.