Purpose/Significance To realize the integrated management of medical insurance payment services, to meet the diversified medical insurance payment needs of patients, and to improve payment efficiency. Method/Process With the help of micro-service business platform architecture, a unified medical insurance payment platform is built, medical insurance data are integrated, and the hospital medical insurance payment process is replanned. A virtualization server deployment method is adopted. Through the standard application programming interfaces, it can connect with the national medical insurance information platform and hospital business system. Data encryption, access control and identity authentication are adopted to protect data security. Result/Conclusion The medical insurance payment system based on micro-service business platform has achieved integration and sharing of medical insurance payment services, which can improve the proportion of hospital medical insurance payments, reduce payment waiting time, and optimize the medical experience.