Purpose/Significance Aiming at the urgent need of traditional Chinese medicine (TCM) research users to acquire knowledge accurately in the ubiquitous knowledge environment, a user interest model is constructed to help the innovative development of TCM research. Method/Process The main dimensions of the user interest model are extracted through the questionnaire survey and semi-structured interview of researchers in various fields and levels of TCM. Based on the grounded theory, the interview data are analyzed deeply, the core categories are determined, and the theoretical framework is constructed. Result/Conclusion The model encompasses 6 core categories, such as researcher portrait and knowledge acquisition, covering the basic procedures and important links of TCM research. This model aims to strengthen knowledge acquisition and application, improve the efficiency of scientific research, and will be used to build a knowledge service platform to provide accurate, intelligent and personalized information resources and knowledge services for TCM researchers.