Purpose/Significance Combined with the characteristics of medical information engineering specialty “medical-engineering intersection”, the paper puts forward the course teaching mode oriented to practice and innovation ability training, so as to meet the needs of high-quality interdisciplinary talents training under the background of new engineering. Method/Process According to the existing problems in C language course teaching, the teaching objectives are adjusted, and the teaching methods are flexibly applied and innovated. The specific measures include increasing medical application cases, making full use of the second classroom, and playing the promotion role of discipline competitions. Result/Conclusion The implementation of this teaching mode greatly stimulates students’ learning interest and initiative, guides students to pay attention to the application of information engineering technology in the medical field, carries out project practices and innovative activities, and significantly improves the teaching effect.