Purpose/Significance To construct a framework for biomedical and health informatics (BMHI) talents with bachelor-master-PhD integrated training, in order to meet the demand for high-level interdisciplinary BMHI professionals in the development of healthcare informatization in China. Method/Process Through analyzing current situation, challenges and international experiences, based on the BMHI education framework, centered on the “multidisciplinary integration, progressive advancement, practice-driven approach, and innovation leadership” concept, a “three-stage, one-system” progressive cultivation model is constructed from four dimensions:teaching objectives, contents, methods, and evaluation. Result/Conclusion The study pioneers the design of BMHI undergraduate major program, establishes a complete bachelor-master-PhD training chain. Based on the IMIA framework, it develops a localized curriculum system. It innovatively proposes implementation strategies and conditional guarantee mechanisms and provides a systematic solution for BMHI education in China.