Purpose/Significance To analyze the promoting effect of the application of artificial intelligence (AI) on precision medical education and the new round of medical education reform, and to provide practical references for AI empowering medical education. Method/Process Taking Harvard Medical School and New York University Grossman School of Medicine as examples, the innovative initiatives and progress of these two institutions, which are at the forefront of medical education reform in the United States, in empowering medical education with AI technology are analyzed. Result/Conclusion Medical universities and colleges in China should strengthen the construction of digital resources, promote AI empowered medical education reform, build a high-quality, high-efficiency, intelligent and precise medical education system, and train AI-enabled physicians. Meanwhile, the management of security, ethics and fairness in the application of AI should also be reinforced.