Purpose/Significance To establish a performance evaluation system for cloud HIS application which is in line with Hainan’s characteristics, and to comprehensively and scientifically evaluate the effectiveness of cloud HIS application. Method/Process Drawing on the balanced score card (BSC) framework, four dimensions of evaluation indicators, namely value contribution, internal process optimization, user satisfaction improvement, and learning and development, are designed. The priority diagram method is used to scientifically assign weights to each evaluation indicator. Result/Conclusion This evaluation system provides theoretical support and practical guidance for the performance evaluation of cloud HIS applications in secondary hospitals in Hainan province.