Purpose/Significance In view of the problems of high technical complexity and low efficiency existing in the database analysis of manufacturer and user facility device experience (MAUDE) of medical devices, to design and implement an automated analysis framework, so as to reduce the difficulty of database analysis and accelerate research output.Method/Process The AutoQUEST framework is designed based on a dual-chain, which has the capabilities of automatic generation of research questions, structured SQL query formulation, and data analysis. Five cases are used to evaluate the framework in terms of query success rates, execution duration, and report quality.Result/Conclusion In the best cases, the framework achieves a 100% query success rate, an execution time of 158 seconds, and an overall quality score of 4.74 out of 5. It can not only achieve efficient and automated analysis of the MAUDE database but also maintain high-quality analysis results, providing convenient and reliable data analysis support for medical institutions, medical device manufacturers, and regulatory authorities.