Purpose/Significance To analyze the information adoption intention and influencing factors of medical college students towards mental health science popularization short videos，and to provide theoretical support and practical references for optimizing the effectiveness of science popularization and improving the mental health literacy of medical students. Method/Process The unified theory of acceptance and use of technology(UTAUT)and the information adoption model(IAM)are integrated. A model of information adoption intention for mental health science popularization short videos is constructed. Taking Shanxi Medical University as an example，questionnaires are distributed both online and offline to collect data，and structural equation modeling(SEM)is applied to verify research hypotheses and analyze the influence paths of factors. Result/Conclusion Factors such as effort expectancy and facilitating conditions have a significant positive impact on medical students’ information adoption intention towards mental health science popularization short videos. Suggestions for optimizing the effectiveness of science popularization are proposed from three aspects:content creation，communication strategies，and source construction.