The paper analyzes the current situation and existing problems of domestic sci-tech journals, including the low influence of papers, uneven distribution structure, repeating publishing problem severe, low editing quality, academic misconduct prominent,excellent manuscripts outflow and low marketing management level, etc. Combining with the editing experiences in the Journal of Medical Research as well as judgement index, the paper points out its advantages and shortages, provides several strategies aiming to provide references for raising influence and competitiveness of sci-tech journals.