The successful implementation of clinical pathway application needs corresponding informatization basis. Combined with the concrete clinical pathways management examples, the paper introduces the constantly improving process of clinical information system, and the clinical informatization construction methods taking clinical pathway as the core. It points out that constantly satisfying clinical medical requirments and improving the software are the key factors for the successful implementation of clinical pathway informatization.Based on the constant improvement of medical business process, it proposes the improvement strategies of electronic medical records taking clinical pathway management as the core.