Hospital website is one of the important components in hospital informatization construction. The paper introduces the meaning and significance of website maintenance. With the combination of the practices at the First Affiliated Hospital of Medical College, Xi′an Jiaotong University, it expounds perfecting website maintenance management mechanism, website security management,website information contents maintenance as well as the website promotion actions and measures. It points out that a website would then have long term development unless the mechanism construction ensures its renews unceasingly and its steady operation.