Taking clinical medical undergraduates from grade 2006 in Jining Medical College as research objects, the paper compares the application effects of problem-based learning (PBL) and lecture-based learning (LBL) in pharmacology teaching using questionnaires. The results show that PBL method values specially in promoting students′ attitudes towards learning, professional knowledge learning and improving students′ learning ability, but PBL can′t completely replace LBL.