In order to evaluate the actual application of the established sci-tech influence evaluation index system for Grade-Ⅲ hospitals in China, the paper selects 1130 hospitals among them, collects data based on the index system, calculates their sci-tech influence level by comprehensive evaluation methods, and analyzes the influence factors by Kruskal-Wallis rank-sum test. As indicated by the results, a statistical difference(P<0.05) exists in the sci-tech influence of hospitals of different grades and types and in different areas. To some extent, the study can provide a basis for national and provincial scientific research administrators to develop and adjust policies of medical scientific researches.