According to the business flow of the physical examination center and its requirements for information management, the paper proposes the physical examination information system based on B/S architecture and makes a detailed introduction to the system's architectural design, development environment and functional applications and realizes information management all through the business flow of physical examination. The results indicate that the system design and application meet the requirements of digitalization, automation and standardization proposed by the physical examination center. Furthermore, the system enhances its work efficiency and management quality.