By using the software CiteSpace II, the paper makes a quantitative analysis and interpretation of research literatures on telemedicine in SCIE of Web of Science from three perspectives, namely the research hotspots, knowledge base and research fronts. The research hotspots of telemedicine mainly include tele-diagnosis, tele-monitoring and evaluation of the application effects of telemedicine. It sets forth key literatures representing the knowledge base one by one and reveals that most of them focus on clinical applications. The analysis of burst terms indicates that more attention has been paid to tele-monitoring and distance education of chronic diseases in recent years and mobile technology is one of the greatest driving forces for the development of telemedicine at the present stage.