Based on the standardization construction for clinical information interconnection of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, the paper introduces the construction of a hospital information integration platform and the transformation and upgrading plan for the existing clinical information system, and successfully establishes a clinical data center, which takes the main index of patients as the main line, is based on the information integration platform and integrates data of different business systems in the whole hospital. Also, it analyzes the application effects. It can be used as reference for the construction of the current hospital clinical information systems, especially for the sharing and interconnection of clinical information.