Based on the practice of Jiangsu Province Hospital, the paper studies the construction and implementation of an information standard system with characteristics of the hospital while giving consideration to domestic and foreign standards. It proposes the method for construction and implementation of health information standard system. This is to establish a standardization organization with clear organization structure and defined division of responsibilities and work, divide the entire work process into four procedures, namely investigation, formulation, implementation, and operation and maintenance, and set up feasible plans and measures for standard formulation.