With the literature analysis software CiteSpace, the paper carries out knowledge map analysis on 731 relevant colorectal cancer research literatures based on gut microbiota included in the Web of Science database from 2000-2015 in the aspects of annual number of published papers, authors, regions, co-citation and co-occurrence. Through the result, heat degree of this field increases year by year, especially in America and China and institutions of higher learning in many countries. The research mainly focuses on some specific microbiota and microbiota metabolic products.