Taking the Ningbo College of Health Sciences as an example, the paper introduces the practice teaching of Hospital Information System(HIS)based on data flow, states the basic teaching situation from the aspects of teaching contents, objectives and existing problems, and particularly discusses the teaching design situation based on data flow from the aspects of teaching process, mode, role playing, evaluation and effect assessment. This teaching mode helps effectively promote learning enthusiasm of students, and assists students to master the learning contents systematically.