Based on Sun Yat-Sen University Cancer Hospital's practice of applying big data for prevention of registration traffickers, the paper analyzes the behavioral characteristics of technology-based registration traffickers' malicious occupation from the aspects of abnormal registration, abnormal withdrawal, abnormal grab and abnormal user binding, makes the corresponding technical plans and countermeasures, so as to limit the malicious registration of registration traffickers using the reservation system and guarantee the medical resources can be distributed to patients fairly and impartially.