The paper analyzes the impact of MOOC on medical information resources construction, and proposes the response strategies for the information resources construction of medical library, including introducing Patron Driven Acquisitions (PDA) mode, strengthening digital resources construction efforts, developing medical MOOC course reference resources system and constructing medical library alliance. Meanwhile, it points out that the medical library is required to dig users'information demand further and solve the issue of MOOC copyright clearance.