The residents health card is an important content for the health informatization construction in the new medical reform. The paper studies the factors that influence the issue and application of residents health card from the perspectives of management, technology and operation, and puts forward countermeasures for future issue and application of the residents health card based on the regional health information platform, namely, the government departments shall pay more attention, explore new operation modes, improve supporting functions of the platform, and establish the residents health card management system.