Based on Web of Science, the paper analyzes the current situation and progress of big data study of the medical informatics subject from the aspects like publication time, countries/regions and institutions, core authors and distribution of major periodicals. It carries out cluster analysis of keywords with the help of software and finds out that subjects of study hotspots mainly focus on such aspects as Clinical Decision Support System(CDSS), clinical research data management, Electronic Healthcare Records(EHR), translational bioinformatics and genetic epidemiology,etc.