The paper introduces the concept of master data and the current study situation of master data management information system in the medical care field, elaborates on the design and building of Traditional Chinese Medicine(TCM) master data management information system in detail, including the coding rule and attribute description of master data, the management procedure and realization mode of master data, the system architecture and functions, and points out that the system is conducive to the realization of TCM information resource sharing and interconnection and interworking.