The online MOOC platform system for medical information retrieval and application is designed,which aims at the characteristics of the teaching and examination of the medical information retrieval course. The paper elaborates on the goal and principle of the system design, development and software and hardware environments, as well as structure and functions, including the two major parts of network foreground and the background, which realize functions like online learning, tests, information release and their management and maintenance, and points out that application of the system is conducive to the improvement of students' information literacy, the reduction of teachers' workload, and the enhancement of teaching efficiency.