The paper puts forward the scientific study frontier detection method based on WordNet ontological semantic enhancement and analysis of the contribution degree of multi-sources data topic, introduces related study situation and method framework, performs empirical analysis, as well as identifies the future development direction of graphene in the medical application field by using multi-sources data such as papers, fund projects and patents comprehensively. Experiments show that the method is able to make up for the defects in the implementation of medical frontier detection with single-sources data, and provides references for the adjustment of the medical development architecture of graphene.