The paper, by taking Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology as an example, elaborates on the design and application of a multidisciplinary cooperation information platform which controls Multiple Drug Resistant Organism(MDROs) infection, including building ideas, system architecture and specific functions, points out that the application of the platform can improve the implementation and execution efficiency of prevention and control measures against MDROs, and thus playing a significant role in remarkably reducing infection risks.