Taking Guigang People's Hospital as an example, the paper introduces the implementation background of intelligent Operation and Maintenance (O&M) and information system O&M situation. The intelligent O&M monitoring platform has been built. It expounds the platform design and application idea and core function realization in detail, and points out that the platform can monitor the hospital business system, software and hardware equipment and other resources timely, positively, comprehensively, three-dimensionally and intelligently.