The paper analyzes the problems and deficiencies of the medical and health informatization building in the COVID-19 epidemic prevention and control, expounds the application and innovation of the medical and health informatization in epidemic prevention and control and puts forward suggestions on the development, including improving the business cooperative ability of regional information platform and building the smart health service system integrating medical and prevention; strengthening overall planning and integration, and realizing cross-level sharing between vertical reporting system and national and regional information platforms, etc.