Combining with the characteristics of “Hospital Information System” course, the thoughts and methods of ideological and political teaching design based on “necklace mode" are put forward, and a new ideological and political teaching system of “Hospital Information System” course has been formed, including teaching objectives, teaching modules, teaching implementation strategies, teaching plans, etc. Based on the results of the questionnaire survey, the paper evaluates the implementation effect of the ideological and political teaching system of the course and summarizes and reflects on how to do a good job in the ideological and political education of medical information specialty.