The paper introduces the progress and results of domestic and foreign health and medical informatization and open sharing of data, analyzes the challenges and difficulties faced by open sharing of health and medical big data in China, expounds the necessity of transforming health and medical big data into scientific data, and puts forward some suggestions, including establishing a mechanism for transforming health and medical big data into scientific data, establishing a national health and medical science data resource catalog, promoting standardized management of health and medical science data, etc.