The paper introduces the research and application status of infectious disease monitoring and early warning, elaborates the architecture design of an intelligent infectious disease monitoring and early warning and disposal system based on big data and 5G technology, the collection and management of multiple heterogeneous data, model design and system function design, and analyzes the application effect of the system. During the trial operation, the system improves the level of infectious disease monitoring and early warning and the efficiency of epidemic disposal, and realizes full closed-loop management.