Purpose/Significance To analyze the strengths and weaknesses, opportunities and threats of “internet plus” chronic disease management under the mode of medical alliance, and to put forward targeted countermeasures and suggestions, so as to provide new ideas for the information management of chronic diseases under the medical alliance mode in China and help promote the strategy of “Healthy China”. Method/Process SWOT analysis is adopted to analyze the application of “internet plus” chronic disease management under the medical alliance mode from four aspects:strengths, weaknesses, opportunities and threats. Result/Conclusion The organic integration of medical alliance mode and internet information technology can effectively alleviate the contradiction between the large number of elderly chronic disease patients in China and the limited and uneven distribution of high-quality health resources.