Purpose/Significance In view of the shortcomings of the traditional teaching mode of health informatics course, the paper explores how to improve students’ ability to solve problems through the flipped classroom teaching mode. Method/Process Based on conventional and creational-driven flipped classrooms, the study compares traditional lecture-based learning and explores the application effects of different teaching modes in the medical informatics courses. Result/Conclusion Flipped classroom teaching significantly increases the learning interest, and the creational-driven flipped classroom obviously improves the students’ability to use knowledge and enhanced the learning effect.