Purpose/Significance Exploring a scientific and effective teaching model to help students absorb theoretical knowledge and implement it into clinical informatization practice.Method/Process The paper explores the teaching means of medical informatics course, designs a mixed teaching mode of “theory+practice+problem-based learning (PBL)”, and applies it to the teaching process of clinical medicine majors of Hainan Medical University. It selects two classes of clinical medicine major in 2018 as the experimental group and the control group respectively. The former adopts the “theory+practice+PBL” teaching mode, while the latter adopts the traditional theory teaching mode.Result/Conclusion The experimental group performs better in statistical analysis than the control group. The teaching model of “theory+practice+PBL” can significantly promote students’ self-directed learning, and harvest better learning outcomes.