Purpose/Significance In recent years, the technology of large language models has been rapidly advancing, and their applications in clinical settings urgently need to be summarized and analyzed. Method/Process Based on a review of relevant literatures, the paper outlines the applications of large language models, represented by ChatGPT, in various clinical fields such as clinical consultation, medical history collection and text writing, clinical decision support, personalized precision medicine, doctor-patient communication and patient psychological support, academic research, medical education, and hospital management. Result/Conclusion Large language models have the potential to completely revolutionize the healthcare ecosystem, despite facing numerous challenges, they will ultimately benefit both doctors and patients.