Purpose/Significance To discuss the development trend of medical informatics, and to provide references for the research and development of medical informatics. Method/Process The research objects are the papers published in 31 medical informatics journals included in SCIE from 2002 to 2021. The bibliometric method and keyword co-occurrence analysis are used to analyze the number of published papers, journals, countries and regions, institutions, authors, funding status, as well as research directions, research hotspots in this field in recent five years. Result/Conclusion The total number of publications in the field of medical informatics has increased rapidly. In the past five years, the research directions have been focused on healthcare science and services, interdisciplinary applications of computer science, mathematics and computational biology, etc., research hotspots have been focused on mobile health, computer technology, electronic medical records (EMR), natural language processing (NLP) technology, etc. This field presents the trend of deep cross-integration of multi-disciplinary fields, expansion to health informatics, open sharing of health and medical data, and medical informatization moving towards smart medical treatment and smart health.